Publications Related to AFC Products

1. Strauer BE, Brehm M, Zeus T, Köstering M, Hernandez A, Sorg RV, Kögler G, Wernet P.  “Repair of Infarcted Myocardium by Autologous Intracoronary Mononuclear Bone Marrow Cell Transplantation in Humans”. Circulation 2002;106:1913-1918.

2. Strauer BE, Brehm M, Zeus T, Bartsch T, Schannwell C, Antke C, Sorg RV, Kögler G, Wernet P, Müller H, Köstering M.  “Regeneration of Human Infarcted Heart Muscle by Intracoronary Autologous Bone Marrow Cell Transplantation in Chronic Coronary Artery Disease”. Journal of the American College of Cardiology 2005;46:1651-1658.

3. Kadarusman J, Bhatia R, McLaughlin J, Lin WR.  “Growing Cholesterol-Dependent NSO Myeloma Cell Line in the Wave Bioreactor System: Overcoming Cholesterol-Polymer Interaction by Using Pretreated Polymer or Inert Fluorinated Ethylene Polymer”.  Biotechnology Progress 2005;21:1341-1346.

4. Akiyama, Y., R. Griffith, P. Miller, G.W. Stevenson, Stacy Lund, D.J. Kanapa, and H.C. Stevenson. "Effects of Adherence, Activation and Distinct Serum Proteins on the In Vitro Human Monocyte Maturation Process." Clinical Investigations Section, Biological Therapeutics Branch, Biological Response Modifiers Program, Division of Cancer Treatment, National Cancer Institute, Frederick Cancer Research Facility, Frederick, MD. Journal of Leukocyte Biology. 1988. 43:224-231.

5. Banchereau, J. B. Schuler-Thurner, A. K. Palucka, and G. Schuler. Baylor Institute fo Immunolgy Research, Dallas, TX. Dept of Dermatology, University of Erlangen, Nuremberg, Nuremberg, Germany.

6. "Dendritic Cells as Vectors for Therapy." Cell. Vol. 106, 271-274, August 10, 2001.

7.  Bawdon, R.E., R.F. Larrson, and K. Magee. "Studies on the Ex Vivo Human Placental Transfer of HIV Infected Macrophages." University of Texas Southwestern Medical Center, Dallas, TX; Children’s National Medical Center, Washington, D.C. July 1994.

8.  Bernard, J, D. Ittelet, A. Christoph, G. Potron, J.C. Adjizian, S.Kochman, and M. Lopez. "Adherent-Free Generation of Functional Dendritic Cells From Purified Blood Monocytes in View of Potential Clinical Use". Hematology and Cell Therapy (1998) 40:17-26.

9. Bhatia, R., P.B. McGlave, J.S. Miller, S. Wissink, W. Lin, and C.M. Verfaillie. "A Clinically Suitable Ex-Vivo Expansion Culture System for LTC-IC and CFC Using Stroma-Conditioned Medium". Stem Cell Laboratory, Division of Hematology, Dept. of Medicine, University of Minnesota, Minneapolis, MN. Experimental Hematology. 1997. 25:980-991.

10. Briddell, R.A., B.P. Kern, K.L. Zilm, G.B. Stoney, and I.K. McNiece. "Purification of CD34+ Cells Is Essential for Optimal Ex Vivo Expansion of Umbilical Cord Blood Cells". Dept. of Developmental Hematology, Amgen Inc., Thousand Oaks, CA. Journal of Hematotherapy. 1997. 6:145-150.

11. Capon, S.M., R.A. Sacher, and H.J. Deeg. "Effective Ultraviolet Irradiation of Platelet Concentrations in Teflon Bags." Division of Hematology and the Program of Bone Marrow Transplantation, Georgetown University and the Lombardi Cancer Research Center, Washington, D.C. Transfusion. Vol. 30, No. 8-1990.

12. Coulon, V., A. Ravaud, S. Huet, and N. Gualde. "In Vitro Production of Human Antigen Presenting Cells Issued From Bone Marrow of Patients With Cancer". Laboratoire d’Immunologie, Institut Bergonie, Centre Regional de Lutte Contre le Cancer, Bordeaux, Cedex, France. Universite Victor Segalen. Hematology and Cell Therapy. 1997. 39:237-244.

13. Dickerson, S.G., A. Mrowca, R.K. Oldham, E. Sharp, G.B. Thurman, and J.R. Yannelli. "An Improved Method for the Generation of Human Lymphokine Activated Killer Cells." Biotherapeutics Inc., and the Biological Therapy Institute, Franklin, TN. Journal of Immunological Methods. 1987.

14. Ellis, J.R. "Plasticizers - Under Scrutiny Again." J.R. Ellis, Inc., Technical and Economic

15. Services, Newtown, PA. Medical Device & Diagnostic Industry. March 1991. 88-89.

16. Foley, R., R. Tozer, R. Meyer, M. Levine, Y. Wan, P. McCulloch, P. Dent, J. Gauldie. "Use of Autologous CD34+ Derived Dendritic Cells Transduced with an Adenovirus Expressing Human gp100 in Patients with Metastatic Melanoma". Henderson General Hospital Site, Hamilton Regional Cancer Centre. McMaster University Medical Centre Site, McMaster University.

17. Garland, R.J., S.S> Kaneria, J.P. Hancock, C.G. Steward, A.W. Rowbottom. "The use of Teflon cell culture bags to expand functionally active CD8+ cytotoxic T lymphocytes." Journal of Immunological Methods 27 (1999) 53-63.

18. Giersch, T., and S. Schapermeier. "Monoclonal Antibody Production in Serum-Free Medium".

19. CSIRO Plant Industry, Canberra ACT, Australia and The Technical University of Munich, Dept. of Botany, Frelsing, Germany. G.I.T. Laboratory Journal. Feb 1998. Pages 113-117.

20. Climm, Hanno, K. Flugge, D. Mobest, V. M. Hofmann, J. Postmus, R. Henschler, W. Lange, J. Finke, H-P. Kiem, G. Schulz, F. Rosenthal, R. Mertelsmann, and C. Von Kalle. "Efficient Serum-Free Retroviral Gene Transfer into Primitive Human Hematopoietic Progenitor Cells by a Defined, High-Titer, Nonconcentrated Vector-Containing Medium." Human Gene Therapy 9:771-778 (April 10, 1998).

21. Dhodapkar, Madhav V., R.M. Steinman, M. Sapp, H. Desai, C. Fossella, J. Krasovsky, S.M. Donahoe, P.R. Dunbar, V. Cerundolo, D.F. Nixon, and N. Bhardwaj. "Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells." Laboratory of Immunology and Cellular Physiology, General Clinical Research Center, and Aaro Diamond AIDS Research Center, Rockefeller, NY, NY. Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford. Oxford OX3 9OU, United Kingdom. Journal of Clinical Investigation. Jul 99, Vol. 104. Number 2.

22. Hubel, A., J. Norman, T.B. Darr. "Cyrobiophysical Characteristics of Genetically Modified Hematopoietic Progenitor Cells. Cryobiology 38, 140-153 (1999).

23. Halberstadt, C.R., Robert Hardin, K. Bezverkow, D. Snyder, L. Allen, and L. Landeen. "The In Vitro Growth of a Three-Dimensional Human Dermal Replacement Using a Single-Pass Perfusion System." Bioprocess Research and Epithelial Research Departments, Advanced Tissue Sciences Inc., La Jolla, CA. Biotechnology and Bioengineering. 1994. 43:740-746.

24. Handgretinger, R., P. Lang, M. Schumm, D. Niethammer, T. Klingebiel. "Transplantation of Highly Purified Stem Cells from Haploidentical and Matched Unrelated Donors in Children". Children’s University Hospital, Hoppe-Seyler-Str.1, 2076 Tuebingen, Germany.

25. Hughes, C., and P. Miller. "Viability of Monocytes Grown in Teflon FEP Bags." National Cancer Institute, Ft. Detrick Laboratories, Frederick, MD. February 1987.

26. Jonuleit, T., H. Glockner, H.D. Lemke, Acordis Research Obernburg, Germany. "Conservation of Hematopoietic Progenitor Cells for 7 Days in a DMSO-Free, Closed and Automated System." (Cytocare).

27. ISHAGE San Diego 2000 Abstracts.

28. Kisiday, M.Jin, B. Kurz, H. Hung, C. Semino, Z. Zhang, and A.J. Grodzinsky. "Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: Implications for Cartilage Tissue Repair." Biological Engineering Division, Departments of Mechanical and Electrical Engineering, Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 4307.

29. Knazek, R.A., Y-W. Wu, P.M. Aebersold, and S.A. Rosenberg. "Culture of Human Tumor Infiltrating Lymphocytes in Hollow Fiber Bioreactors." Cellco Advanced Bioreactors, Inc., Kensington, MD, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD and Surgery Branch, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, MD.

30. Journal of Immunological Methods. 1990. 127:29-37.

31. Kretschmer, V., L. Cronemeyer, and G.L. Dederichs. "Teflon Bags for 5-Day Storage of Platelet

32. Concentrates (PC) from Cell Separator." Department of Transfusion Medicine and Coagulation Physiology, University Hospital, Marburg, Federal Republic of Germany. Infusionstherapie. 1992.

33. 19:64-69.

34. Mackensen, A., R. Drager, M. Schlesier, R. Mertelsmann, A. Lindemann. "Presence of IgE antibodies to bovine serum albumin in a patient developing anaphylaxis after vaccination with human peptide-pulsed dendritic cell." Cancer Immunol Immunother (2000) 49:152-156.

35. Mackensen, A., B. Herbst, J-L. Chen, G. Kohler, C. Noppen, W. Herr, GC. Spagoli, V. Cerundolo, and A. Lindemann. "Phase I Study in Melanoma Patients of a Vaccine With Peptide-Pulsed Dendritic Cells Generated IN VITRO From CD34+ Hematopoietic Progenitor Cells." Dept of Hematology Oncology, Dept of Pathology, Freiburg University Medical Center, Freiburg, Germany. Institute of Molecular Medicine, Nuffield Dept of Clinical Medicine, Oxford, UK. Research Division, Dept of Surgery, University of Basel, Basel, Switzerland. Johannes Gutenberg Universitat Mainz, III Medizinische Klinik, Mainz, Germany.

36. Martinson, J.A., K. Doligosa, H-G. Klingemann, Y.K. Tam, "Ex Vivo Expansion of a Highly Cytotoxic Human Natural Killer Cell Line Under cGMP Conditions, for Clinical Adoptive Cellular Immunotherapy". Rush Cancer Institute, Rush Presbyterian-St. Luke’s Medical Center, Rush Medical School, Rush University, BMT and Cell Therapy, Chicago, IL.

37. Miller, J.S., S. Klingsporn, J. Lund, E.H. Perry, C. Verfaillie, and P. McGlave. "Large Scale

38. Ex Vivo Expansion and Activation of Human Natural Killer Cells for Autologous Therapy." Bone Marrow Transplantation. Macmillan Press Ltd. 1994. 14:555-562.

39. Mobest, Dieter, S-R. Goan, I. Junghahn, J. Winkler, I. Fichtner, M. Hermann, M. Becker, E. De Lima-Hahn, R. Henschler. "Differential Kinetics of Primitive Hematopoietic Cells Assayed In Vitro and In Vivo During Serum-Free Suspension Culture of CD34+ Blood Progenitor Cells." Experimental Hematology Group, Department of Hematology/Oncology, University Medical Center, Freiburg, Germany. Department of Experimental Pharmacology, Max-Delbruck-Center for Molecular Medicine, Berlin, Germany; present address: Medical Center III; Friedrich-Alexander-University, Erlangen, Germany. Stem Cells 1999; 17:152-161.

40. Muul, L.M., K. Nason-Burchenal, C.S. Carter, H. Culls, D. Slavin, C. Hyatt, E.P. Director, S.F. Leitman, H.G. Klein, and Steven A. Rosenberg. "Development of an Automated Closed System for Generation of Human Lymphokine-Activated Killer (LAK) Cells for use in Adoptive Immunotherapy." Surgery Branch, National Cancer Institute, Dept of Transfusion Medicine, National Institutes of Health, Bethesda, MD 20892, and Fenwal Laboratories, Division of Travenol Laboratories, Deerfield, IL. USA. Journal of Immunological Methods, 101. 1987. 171-181.

41. Muul, L.M., E.P. Direcotr, C.L. Hyatt, and S.A.Rosenberg. "Large scale production of human lymphokine activated killer cells for use in adoptive immunotherapy". Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. Journal of Immunological Methods, 88. 1986. 265-275.

42. Nardone, R.M., and M.E. Kaighn. "Growth of Mammalian Cells in Teflon Bags." The Center for Advanced Training in Cell and Molecular Biology. The Catholic University of America, Washington, D.C.

43. Naughton, B.A. and G.K. Naughton. "Hematopoiesis on Nylon Mesh Templates Comparative

44. Long-Term Bone Marrow Culture and the Influence of Stromal Support Cells." Medical

45. Laboratory Sciences, Hunter College School of Health Sciences, New York, NY. Reprinted from Molecular and Cellular Controls of Hematopoiesis. Vol. 554 of the Annals of the New York Academy of Sciences. May 1, 1989.

46. Negrin, R.S., C.R. Kusnierz-Glaz, B.J. Still, J.R. Schriber, N.J. Chao, G.D. Long, C. Hoyle, W.W. Hu, S.J. Horning, B.W. Brown, K.G. Blume, and Samuel Strober. "Transplantation of Enriched and Purged Peripheral Blood Progenitor Cells From a Single Apheresis Product in Patients With Non-Hodgkin’s Lymphoma." Blood. Vol 85, No. 11 (June 1), 1995: pp 3334-3341.

47. Paquette, R.L., S.T. Dergham, E. Karpf, H-J. Wang, D.J. Slamon, L. Souza, J.A. Glaspy. "Ex vivo expanded unselected peripheral blood: progenitor cells reduce posttransplantation neutropenia, thrombocytopenia, and anemia in patients with breast cancer". Blood. Oct 2000. Vol 96, No. 7.

48. Purdy, M.H., C.J. Hogan, L. Hami, I. McNiece, W. Franklin, R.B. Jones, S.I. Bearman, R.J. Berenson, P.J. Cagnoni, S.Heimfeld, and E.J. Shpall. "Large Volume Ex Vivo Expansion of CD34-Positive Hematopoietic Progenitor Cells for Transplantation". Journal of Hematotherapy.

49. 1995. 4:515-525.

50. Reiffers, Josy, C. Cailliot, B. Dazey, I. McNiece, P. Duchez, A. Pigneux, J. Caraux, T. Cousin,

51. B. Bussiere, J.M. Boiron, "Clinical experience with ex-vivo expansion of haematopoietic progenitor cells." BMT Unit, CHU de Bordeaux, Pessac, France, Amgen SA, Paris; Dept of Cell Therapy, Blood Centre, ETSA, Bordeaux, France. University of Colorado HSC.

52. Schneider, U., P. Mazur, "Relative Influence of Unfrozen Fraction and Salt Concentration on the Survival of Slowly Frozen Eight-Cell Mouse Embryos". University of Tennessee, Oak Ridge Graduate School of Biomedical Science and Biology Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831. Cryobiology. 1987. 24:17-41

53. Shapiro, F., T-J. Yao, G. Raptis, L. Reich, L. Norton, and M.A.S. Moore. "Optimization of

54. Conditions for Ex Vivo Expansion of CD34⁺ Cells from Patients with Stage IV Breast Cancer". James Ewing Laboratory of Developmental Haematopoietic and the Breast and Gynecological Service of the Solid Tumor Division, Memorial Sloan-Kettering Cancer Center, New York, N.Y. Blood. Vol. 84, No. 10, November 15, 1994: 3567-3574.

55. Sitrin, R.G., P.M. Pan, S. Srikanth, and R.F. Todd III. "Fibrinogen Activates NF-kB Transcription Factors in Mononuclear Phagocytes¹. Pulmonary and Critical Care Medicine Division and Hematology-Oncology Division, Dept of Internal Medicine, University of Michigan, Ann Arbor, MI. The Journal of Immunology. 1998. 161:1462-1470.

56. Stevenson, H.C., E. Schlick, R. Griffith, M.A. Chirigos, R. Brown, J. Conlon, D.J. Kanapa,

57. R.K. Oldham, and P. Miller. "Characterization of Biological Response Modifier Release by Human Monocytes Cultured in Suspension in Serum-Free Medium¹". Biological Therapeutics Branch, Biological Response Modifiers Program, National Cancer Institute, Frederick Cancer Research Facility and the Viral Carcinogenesis Program, Basic Research Program, Frederick Cancer Research Facility, Frederick, MD. Journal of Immunological Methods. 1984. 70:245-255.

58. Stroncek, D.F., A. Hubel, R.A. Shankar, S.R. Burger, D. Pan, J. McCullough, and C.B. Whitley.

59. "Retroviral Transduction and Expansion of Peripheral Blood Lymphocytes for the Treatment of Mucopolysaccharidosis Type II, Hunter’s Syndrome." Cell Therapy Clinical Lab, Dept of Laboratory Medicine and Pathology, Dept of Pediatrics; and Gene Therapy Program Institute of Human Genetics, University of Minnesota, Minneapolis, MN. Transfusion. 1999. 39:343-350.

60. Tedder, R.S., M.A. Zuckerman, A.H. Goldstone, A.E. Hawkins, A. Fielding, E.M. Briggs,

61. D. Irwin, S. Blair, A.M. Gorman, K.G. Patterson, D.C. Linch, J. Heptonstall, and N.S. Brink. "Hepatitis B Transmission From Contaminated Cryopreservation Tank." Division of Virology, University College London Medical School, London, UK; Department of Haematology, University College Hospital, London, UK; Academic Department of Genitourinary Medicine, Mortimer Market, London, UK; NE Thames Regional Transfusion Centre, Essex, UK and PHLS Communicable Disease Surveillance Centre, London, UK. The Lancet. 1995. Vol. 346.

62. Tjota, A., T.M. Rossi, and B.A. Naughton. "Stromal Cells Derived from Spleen or Bone Marrow Support the Proliferation of Rat Natural Killer Cells in Long-Term Culture." Medical Laboratory Sciences Department, Hunter College School of Health Sciences, New York, N.Y. The Society for Experimental Biology and Medicine. Vol. 200, 1992.

63. Webb, I.J., F.S. Coral, J.W. Andersen, A.D. Elias, R.W. Finberg, L.M. Nadler, J. Ritz, and

64. K.C. Anderson. "Sources and Sequelae of Bacterial Contamination of Hematopoietic Stem Cell Components: Implications for the Safety of Hematotherapy and Graft Engineering". From the Blood Component Laboratory and the Divisions of Hematologic Malignancies, Medical Oncology, Biostatistics, Infectious Diseases, and Cancer Pharmacology, Dana-Farber Cancer Institute and the Dept. of Medicine, Harvard Medical School, Boston, MA. Transfusion. 1996. 36:782-788.

65. Yannelli, J.R. "A Comparison of the Effectiveness of Lak Cells Grown in FEP Teflon Bags vs. Cells Grown in PL732 Bags." NCI, Ft. Detrick Laboratories, Frederick, MD. 1987. (Monograph available from AFC)